I honestly have no idea who would play him, but I can imagine what he would look like. Brown hair in a ponytail, maybe a little bit of stubble on his chin or even a goatee (I just feel like he's the goatee type
), pale-ish. He never struck me as nerd-looking. As for the anime part, do you mean as in computer generated? Because if Foaly was anime, then the whole movie would be anime. But if his centaur half was computer generated, then the rest of the movie could still have real people as actors, if you know what I mean.